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Jian-Chao Chen
chen3305@umn.edu

 

 

 

Education
2001-2006: Ph. D., Natural Products Chemistry, Kunming Institute of Botany, Chinese Academy of  Sciences, China. Advisor: Prof. Ming-Hua Qiu
1990-1995: B.Sc., Chemistry,  Sichuan University, Chengdu, China.


Current position
December 2012- current: Postdoctoral researcher at University of Minnesota with Professor Peter W. Carr.


Research experience

Current research focuses on:  

  1. Detecting samples, including plant materials, by using synthesized silica on 2D HPLC.  

Previous research experience:  

Many plants in China are used as traditional Chinese medicine by local people. For example, some of Hemsleya spp. tubers have been used as antibacterial remedy to treat sore throat, toothache, dysentery, bronchitis, and chronic cervicitis, while the fruits, vines, leaves and roots of Momordica charantia L. have been used in China for treating toothache, diarrhea, furuncle and diabetes mellitus. From the medicinal plants, especially genus Hemsleya and M. charantia, more than 200 natural compounds, including at least 80 new ones, were obtained. Some of the new compounds bear novel structures, such as tri-, penta-, and octa-cucurbitane structures. Some isolates showed obvious anti-cancer, anti-HIV, or hypoglycemic bioactivities.


Publications

  1. Jian-Chao Chen, Lin Zhou, Yun-Hua Wang, Ren-Rong Tian, Yun-Xin Yan, Yin Nian, Yun Sun, Yong-Tang Zheng, Ming-Hua Qiu. Cucurbitane triterpenoids from Hemsleya penxianensis. Nat. Prod. Bioprospect. 2012, 2(4), 138-144.
  2. Jian-Chao Chen, Zhong-Zhi Xu, Li-Xin Yang, Xiu-Yun He, Cui Chen, Gao-Hong Zhang, Yong-Tang Zheng, Ming-Hua Qiu. A new N-containing cucurbitacin from Hemsleya endecaphylla.Chemistry of Natural Compounds, 2012, 48: 591-593.
  3. Jian-Chao Chen, Wu-Qing Liu, Lu Lu, Ming-Hua Qiu, Yong-Tang Zheng, Liu-Meng Yang, Xian-Ming Zhang, Lin Zhou, Zhong-Rong Li. Kuguacins F-S, new cucurbitane triterpenoids from Momordica charantia, Phytochemistry 2009, 70: 133–140.
  4. Jian-Chao Chen, Ren-Rong Tian, Ming-Hua Qiu, Lu Lu, Yong-Tang Zheng, Zhong-Quan Zhang. Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia. Phytochemistry 2008,69: 1643–1648.
  5. Jian-Chao Chen, Lu Lu, Xian-Ming Zhang, Lin Zhou, Zhong-Rong Li, Ming-Hua Qiu. Eight new cucurbitane glycosides, kuguaglycosides A-H, from the roots of Momordica charantia. Helv. Chim. Acta 2008, 91: 920–929.
  6. Jian-Chao Chen, Gao-Hong Zhang, Zhong-Quan Zhang, Ming-Hua Qiu, Yong-Tang Zheng, Liu-Meng Yang, Kai-Bei Yu. Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity. J. Nat. Prod. 2008, 71: 153–155.
  7. Jian-Chao Chen, Zhong-Quan Zhang, Ming-Hua Qiu. Chemical constituents from the tubers of Hemsleya delavayi. Acta Chimica Sinica 2007, 65: 1679–1684.
  8. Jian-Chao Chen, Ming-Hua Chiu, Rui-Lin Nie, Geoffrey A. Cordell, Samuel X. Qiu. Cucurbitacins and cucurbitane glycosides: structures and biological activites. Nat. Prod. Rep. 2005, 22: 386–399.
  9. Jian-Chao Chen, Xue-Mei Niu, Zhong-Rong Li, Ming-Hua Qiu. Four new cucurbitane glycosides from Hemsleya jinfushanensis. Planta Med. 2005, 71: 983–986.
  10. Lu Lu, Jian-Chao Chen,Yan Li,Chen Qing,Yuan-Yuan Wang,Yin Nian, Ming-Hua Qiu*. Studies on the constituents of Cimicifuga foetida collected in Guizhou Province and their cytotoxic activities. Chem. Pharm. Bull. 2012,60(5): 571-577.
  11. Jie-Qing Liu, Cui-Fang Wang, Yan Li, Jian-Chao Chen, Lin Zhou, Ming-Hua Qiu. Limonoids from the leaves of Toona ciliata var. yunnanensis. Phytochemistry 2012, 76: 141-149.
  12. Jie-Qing Liu, Cui-Fang Wang, Jian-Chao Chen, Ming-Hua Qiu. Limonoids from the leaves of Swietenia macrophylla. Natural Product Research 2012, 26: 1887-1891.
  13. Jin-Xiong Chen, Jian-Chao Chen, Yun Sun, Yu-Xin Yan, Ling-Mei Kong, Yan Li, Ming-Hua Qiu. Cytotoxic triterpenoids from Azadirachta indica. Planta Medica 2011, 77(16): 1844–1847.
  14. Zhong-Quan Zhang,Jian-Chao Chen, Jian Yan,Ming-Hua Qiu. Three steroids with unique structural feature of 5b-Spirostan-1b,3b,17a-trihydroxyl from Reineckia carnea. Chem. Pharm. Bull. 2011,59(1): 53–56.
  15. Yu-Xin Yan, Yun Sun, Jian-Chao Chen, Yuan-Yuan Wang, Yan Li, Ming-Hua Qiu.   Cytotoxic steroids from Sarcococca saligna. Planta Med. 2011, 77: 1725–1729.
  16. Yu-Xin Yan, Yun Sun, Jian-Chao Chen, Jia Su, Yan Li, Ming-Hua Qiu. A new     triterpenoid alkaloid from Buxus sempervirens. Z. Naturforsch. 2011, 66b: 1076–1078.
  17. Jie-Qing Liu, Cui-Fang Wang, Xing-Yao Li, Jian-Chao Chen, Yan Li, Ming-Hua Qiu. One new pregnane glycoside from the seeds of cultivated Brucea javanica. Archives of Pharmacal Research 2011, 34 (8): 1297–1300.
  18. Yin Nian, Xian-Min Zhang, Yan Li , Yuan-Yuan Wang , Jian-Chao Chen, Lu Lu, Lin Zhou, Ming-Hua Qiu. Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus. Phytochemistry 2011, 72: 1473–1481.
  19. Yu-Xin Yan, Lin Zhou, Yun Sun, Jian-Chao Chen, Jia Su, Yan Li, Ming-Hua Qiu. Triterpenoid alkaloid derivatives from Buxus rugulosa. Nat. Prod. Bioprospect. 2011, 1: 71–74.
  20. Jie-Qing Liu, Jian-Chao Chen, Cui-Fang Wang, Ming-Hua Qiu. One new cucurbitane triterpenoid from the fruits of Momordica charantia. European Journal of Chemistry 2010, 1: 294–296.
  21. Cui-Fang Wang, Jie-Qing Liu, Yu-Xin Yan, Jian-Chao Chen, Yang Lu, Yong-Hui Guo, and Ming-Hua Qiu. Three new triterpenoids containing four-membered ring from the fruiting body of Ganoderma sinense. Org. Lett. 2010, 12: 1656–1659.
  22. Yin Nian, Yan-Li Zhang, Jian-Chao Chen, Lu Lu, Ming-Hua Qiu, and Chen Qing.    Cytotoxic chemical constituents from the roots of Cimicifuga fetida. J. Nat. Prod. 2010, 73: 93–98.
  23. Yun Sun, Yu-Xin Yan, Jian-Chao Chen, Lu Lu, Xian-Min Zhang, Yan Li, Ming-Hua Qiu. Pregnane alkaloids from Pachysandra axillaris. Steroids 2010, 75: 818–824.
  24. Yu-Xin Yan, Jian-Chao Chen, Yun Sun, Xian-Min Zhang, Lin Zhou, Ming-Hua Qiu. Triterpenoid alkaloids from Buxus microphylla. Chemistry & Biodiversity 2010, 7: 1822–1827.
  25. Lu Lu,Jian-Chao Chen,He-Jiao Song,Yan Li,Yin Nian,and Ming-Hua Qiu. Five new triterpene bisglycosides with acyclic side chains from the rhizomes of Cimicifuga foetida L. Chem. Pharm. Bull. 2010, 58: 729–733.
  26. Yin Nian, Jian-Chao Chen, Lu Lu, Xian-Min Zhang, Lin Zhou, Ming-Hua Qiu. Four new 9,19-cyclolamostane derivatives from the rhizomes of Cimicifuga yunnanensis Hsiao. Helv. Chim. Acta 2009, 92: 112–120.
  27. Yu-Xin Yan, Xiao-Dong Hu, Jian-Chao Chen, Yun Sun, Xian-Min Zhang, Cheng  Qing, Ming-Hua Qiu. Cytotoxic triterpenoid alkaloids from Buxus microphylla. J. Nat. Prod. 2009, 72: 308–311.
  28. Bao-Hui Cheng, Jian-Chao Chen, Ming-Hua Qiu. A new monoterpenoid indole alkaloid from Rauvolfia yunnanensis. Chin. Chem. Lett. 2009,20: 1221–1223.
  29. Zhen-Jie Li, Jian-Chao Chen, Yun Sun, Na-Li Song, Bao-Hui Cheng, Lu Lu,   Wei-Guang Ma; Lin Zhou, Xian-Min Zhang, Zhong-Rong Li, Ming-Hua Qiu. Three new triterpene saponins from Hemsleya chinensis. Helv. Chim. Acta 2009,92: 1853–1859.
  30. Jie-Qing Liu, Jian-Chao Chen, Cui-Fang Wang, Ming-Hua Qiu. New cucurbitane triterpenoids and steroidal glycoside from Momordica charantia. Molecules 2009,14: 4804–4813.
  31. Lu Lu, Jian-Chao Chen, Yin Nian, Yun Sun, Ming-Hua Qiu. Trinor-cycloartane  Glycosides from the Rhizomes of Cimicifuga foetida. Molecules 2009,14: 1578–1584.
  32. Zhong-Quan Zhang, Jian-Chao Chen, Xian-Ming Zhang, Zhong-Rong Li, Ming-Hua Qiu. Two new spirostanol saponins from Reineckia carnea. Helv. Chim. Acta 2008, 91: 1494–1499.
  33. Ren-Rong Tian, Jian-Chao Chen, Gao-Hong Zhang, Ming-Hua Qiu, Yun-Hua Wang, Li Du, Xu Shen, Nai-Fa Liu, Yong-Tang Zheng. Anti-HIV-1 activities of hemslecins A and B. Chinese Journal of Natural Medicines. 2008, 6: 214–218.
  34. Zhong-Quan Zhang, Jian-Chao Chen, Ming-Hua Qiu. Two new bisdesmosides from Reineckis carnea. Helv. Chim. Acta  2007, 90: 616–622.